Michael Karin Selected Research

Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)

1/2017	YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
11/2012	Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
8/2012	Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Michael Karin Research Topics

Disease

116	Neoplasms (Cancer) 01/2024 - 04/2002
115	Inflammation (Inflammations) 01/2024 - 03/2002
44	Carcinogenesis 01/2023 - 04/2003
19	Hepatocellular Carcinoma (Hepatoma) 03/2023 - 03/2009
18	Liver Neoplasms (Liver Cancer) 01/2023 - 07/2007
17	Infections 09/2014 - 03/2002
15	Neoplasm Metastasis (Metastasis) 10/2022 - 09/2004
15	Obesity 12/2021 - 11/2002
14	Fibrosis (Cirrhosis) 03/2023 - 12/2005
14	Necrosis 07/2014 - 06/2005
11	Insulin Resistance 01/2023 - 11/2002
10	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 11/2012
9	Non-alcoholic Fatty Liver Disease 01/2023 - 11/2017
8	Liver Cirrhosis (Hepatic Cirrhosis) 03/2023 - 01/2013
8	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 04/2007
7	Liver Diseases (Liver Disease) 05/2023 - 01/2016
7	Autoimmune Diseases (Autoimmune Disease) 01/2023 - 01/2010
7	Fatty Liver 10/2022 - 03/2016
7	Breast Neoplasms (Breast Cancer) 09/2014 - 04/2003
7	Carcinoma (Carcinomatosis) 03/2012 - 04/2003
6	Type 2 Diabetes Mellitus (MODY) 12/2021 - 11/2002
5	Hypoxia (Hypoxemia) 12/2019 - 06/2008
5	Arthritis (Polyarthritis) 09/2012 - 03/2002
4	Overnutrition 01/2023 - 10/2008
4	Alcoholic Fatty Liver 03/2021 - 03/2016
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2020 - 09/2008
4	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020 - 01/2007
3	Adenocarcinoma 01/2021 - 03/2010
3	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2020 - 03/2016
3	Shock 01/2018 - 02/2006
3	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2017 - 08/2012
3	Lung Neoplasms (Lung Cancer) 01/2016 - 01/2009
3	Melanoma (Melanoma, Malignant) 12/2014 - 07/2010
3	Bacterial Infections (Bacterial Infection) 01/2012 - 09/2007
3	Anthrax 06/2008 - 03/2004
2	Bites and Stings (Sting) 01/2023 - 01/2022

Drug/Important Bio-Agent (IBA)

57	NF-kappa B (NF-kB)IBA 05/2022 - 04/2002
46	CytokinesIBA 10/2022 - 11/2002
35	Phosphotransferases (Kinase)IBA 01/2022 - 11/2002
27	Transcription Factors (Transcription Factor)IBA 05/2022 - 12/2002
23	Proteins (Proteins, Gene)FDA Link 01/2023 - 12/2002
22	I-kappa B KinaseIBA 03/2013 - 05/2003
19	Interleukin-6 (Interleukin 6)IBA 01/2023 - 06/2005
12	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 09/2004
11	AntigensIBA 01/2022 - 04/2006
10	CarcinogensIBA 01/2019 - 10/2007
9	Interleukin-17 (Interleukin 17)IBA 01/2020 - 03/2007
8	InflammasomesIBA 01/2023 - 09/2014
7	AntioxidantsIBA 01/2020 - 03/2005
7	Insulin (Novolin)FDA Link 01/2020 - 11/2002
7	Mechanistic Target of Rapamycin Complex 1IBA 01/2016 - 06/2010
6	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 07/2006
6	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2020 - 07/2004
6	InterleukinsIBA 03/2015 - 06/2008
5	LigandsIBA 01/2023 - 02/2006
5	CateninsIBA 01/2023 - 08/2012
5	Fatty Acids (Saturated Fatty Acids)IBA 10/2020 - 10/2006
5	Protein Kinases (Protein Kinase)IBA 01/2020 - 01/2005
5	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2019 - 03/2009
5	Lymphotoxin-alpha (Lymphotoxin)IBA 05/2015 - 10/2009
5	p38 Mitogen-Activated Protein KinasesIBA 12/2014 - 10/2002
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2024 - 08/2004
4	CollagenIBA 09/2023 - 12/2005
4	CholesterolIBA 01/2023 - 01/2020
4	ChemokinesIBA 05/2022 - 08/2009
4	SestrinsIBA 01/2016 - 06/2010
4	LipopolysaccharidesIBA 10/2013 - 09/2004
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2013 - 07/2006
4	Toll-Like Receptors (Toll-Like Receptor)IBA 06/2011 - 01/2009
3	Biomarkers (Surrogate Marker)IBA 01/2023 - 11/2017
3	Peptides (Polypeptides)IBA 01/2023 - 06/2011
3	Caspase 2IBA 11/2022 - 01/2018
3	FructoseIBA 10/2022 - 10/2020
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2003
3	Immune Checkpoint InhibitorsIBA 01/2021 - 01/2020
3	Interleukin-10 (Interleukin 10)IBA 11/2017 - 01/2012
3	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2016 - 01/2010
3	Interleukin-23 (Interleukin 23)IBA 07/2015 - 11/2012
3	EnzymesIBA 09/2014 - 02/2005
3	MicroRNAs (MicroRNA)IBA 04/2014 - 12/2011
3	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 09/2012 - 02/2009
3	JNK Mitogen-Activated Protein KinasesIBA 09/2011 - 03/2002
3	B-Cell Activating FactorIBA 11/2010 - 09/2006
3	Protein Isoforms (Isoforms)IBA 01/2009 - 03/2002
2	Angiotensin Receptors (Angiotensin II Receptor)IBA 03/2023 - 01/2023
2	Losartan (Cozaar)FDA LinkGeneric 03/2023 - 01/2023
2	Antihypertensive Agents (Antihypertensives)IBA 03/2023 - 01/2023
2	LipidsIBA 01/2023 - 10/2020
2	Cholesterol Esters (Cholesteryl Esters)IBA 01/2023 - 01/2023
2	Interferon Type IIBA 01/2023 - 01/2010
2	IronIBA 01/2023 - 01/2022
2	Conditioned Culture MediaIBA 01/2023 - 01/2009
2	Mitochondrial DNA (mtDNA)IBA 01/2023 - 01/2022
2	InterferonsIBA 01/2023 - 09/2010
2	Activating Transcription Factor 4IBA 01/2023 - 12/2020
2	Matrix Metalloproteinases (MMPs)IBA 10/2022 - 12/2010

Therapy/Procedure

40	Therapeutics 09/2023 - 11/2002
10	Immunotherapy 01/2022 - 01/2015
6	Drug Therapy (Chemotherapy) 01/2021 - 01/2009
3	Castration 10/2014 - 03/2010